English: “The voice” — this is Hadrian… “the voice of Yaakov” — this is Vespasian… “and the hands are the hands of Esav” — this is the Roman Empire.
On the daf / in context: Yitzchak prophetically perceived the future suffering under Rome; the dual voice-and-hands formula is applied to the destruction of Beitar and the Temple.
Type of Learning
Custom (Bavli — prophetic vision of Roman destruction)
What Is Learned
The phrase “the voice is the voice of Yaakov but the hands are the hands of Esav” alludes to the future Roman oppression of Israel.